This is among the most common forms of adrenal insufficiency (AI) (11), caused by GC-mediated suppression of the hypothalamic–pituitary–adrenal (HPA) axis through negative feedback on corticotropin-releasing hormone and adrenocorticotropic hormone (ACTH) release, leading to corticotroph and adrenal atrophy. This evidence concerns the gene POMC and Adrenal insufficiency.