Multivariate logistic regression identified four independent relapse risk factors: thrombocytopenia at diagnosis [OR 2.089 (95% CI, 1.046–4.213), P = 0.037], BCR::ABL1(+) ALL [OR 3.846 (95% CI, 1.195–12.376), P = 0.024], positive D19-MRD [OR 2.092 (95% CI, 1.005–4.353), P = 0.048], and positive D46-MRD [OR 5.733 (95% CI, 2.926–11.230), P < 0.001] (Figure 1). This evidence concerns the gene BCR and acute lymphoblastic leukemia.