CSF3 and Decreased total leukocyte count: The SOX regimen (oxaliplatin + S-1) commonly induces gastrointestinal toxicities (diarrhea, nausea/vomiting, mucositis), hematological complications (neutropenia, thrombocytopenia), and neurological symptoms (acute/cumulative peripheral sensory neuropathy) (15) G-CSF—primarily used to prevent/treat chemotherapy-induced leukopenia—stimulates neutrophil/monocyte maturation and mobilizes mature cells into peripheral blood (16, 17).