However, when the GDM rats were treated with the high and low doses of berberine nano-formulations (HBN and LBN groups), decreased values of GSH, SOD, CAT, and GPx were significantly and dose-dependently elevated by (0.46-fold (p < 0.0001) and 0.16-fold (p = 0.01)), (0.67-fold (p < 0.0001) and 0.38-fold (p = 0.002)), (0.65-fold (p < 0.0001) and 0.32-fold (p = 0.003)), and (0.81-fold (p < 0.0001) and 0.42-fold (p < 0.0001)), respectively, in comparison with the GDM group. The gene discussed is CAT; the disease is gestational diabetes.