CISH and neoplasm: For instance, knockout of inhibitory genes such as cytokine-inducible SH2-containing protein (CISH) markedly enhances the aerobic glycolytic capacity of iPSC-NK cells by alleviating suppression of the mTOR pathway, yielding a threefold improvement in in vitro expansion efficiency and extending anti-tumor persistence to more than 40 days in xenograft models.