Traditionally, serum tumor markers, such as carcinoembryonic antigen (CEA), squamous cell carcinoma antigen (SCC‐Ag), cytokeratin 19 fragment 21‐1 (CYFRA21‐1), and serum p53 antibody, have been widely used in the diagnosis of esophageal cancer [9, 10, 11]. This evidence concerns the gene CEACAM5 and neoplasm.