In the overall AD group, CDR‐SOB (β = 0.103, p = 0.013, R2 = 0.174), CSF t‐tau (β = 0.001, p = 0.001, R2 = 0.275), and CSF p‐tau (β = 0.008, p = 0.049, R2 = 0.113) were significantly associated with CSF TMEM119 levels. Here, TMEM119 is linked to Alzheimer disease.