Although we observed a pronounced increase in Treg cell frequency among spinal cord infiltrates in the EAE model and focused our investigation on the AMPAR’s role in CD4 T cell metabolism and Treg differentiation, we cannot exclude the possibility that AMPAR-deficient CD4+ Tconv cells also exhibit subtle phenotypic changes that contribute to the observed protection from severe autoimmune disease. Here, CD4 is linked to autoimmune disease.