MYC and non-small cell lung carcinoma: Additionally, USP28-mediated FOXK1 deubiquitination activates the Hippo signaling pathway to regulate cell proliferation and radiosensitivity (36), while targeting USP47 enhances the efficacy of KRAS G12C inhibitors in mutant non-small cell lung cancer through regulation of c-Myc deubiquitination (37).