NR3C1 and triple-negative breast carcinoma: In contrast, in the more aggressive subtype of triple-negative breast cancer (TNBC), Dex disrupts TLS homeostasis through distinctly different mechanisms (4): In terms of lymphocyte homing, Dex significantly downregulates the expression of secondary lymphoid chemokines CCL19 and CCL21 in a GR-dependent manner, impairing DC-mediated T cell activation.