STAT1 and neoplasm: Under inflammatory conditions, HIF-1α is stabilized in a tumor, even under normoxia, through signaling pathways such as the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 1 (STAT1) axis, activated by IFN-γ, or the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and mTORC1 pathways (45).