We hypothesized that IFN and poly(I:C) exposure alters myobundle myokine production, that treatment-naïve JDM patients have altered proinflammatory myokine profiles compared to controls, and that differences in myokine profiles between untreated and treated myobundles are similar to differences between healthy and JDM patients. This evidence concerns the gene IFNA1 and juvenile dermatomyositis.