When comparing myokine profiles of the myobundle model with patients, 6 of 13 measured myokines (IL-6, IL-15, IL-18, CXCL9, CXCL10, and IFNβ) were significantly increased in both JDM patient sera and treated myobundle media compared to controls. The gene discussed is IFNB1; the disease is juvenile dermatomyositis.