This modification process is finely regulated by three types of regulatory proteins (Figure 3): “writers” such as p300, GCN5, and HBO1 catalyze the modification (51), with HBO1 participating in tumor progression through mediating H3K9la; “erasers” such as SIRT1 remove the modification, and its activator resveratrol can improve cardiac function (52); “readers” such as DPF2 regulate gene expression by recognizing modification sites like H3K14la (53). This evidence concerns the gene EP300 and neoplasm.