TLR4 and adenomyosis: Overall, adenomyosis immunological profile is characterized by pronounced proinflammatory changes, including TLR4 signaling pathway activation and reduced immunosuppressive Treg cells, while M2 macrophages enhance pathological process through secretion of tissue remodeling and angiogenesis factors, despite presence of some compensatory mechanisms in the form of increased IL-10 (Figure 4).