TNF and endometriosis: Peritoneal endometriosis, being the most common form, demonstrates stage-dependent immune evolution: early stages (I-II) show M1 macrophage dominance with elevated IL-6/IL-8/TNF-α despite reduced cytotoxicity, while advanced stages (III-IV) exhibit M2 polarization driven by chronic DAMP stimulation and endometriotic cell-derived TGF-β/IL-10.