Corticosterone-induced inhibition of GSK3β, through its phosphorylation at serine 9, a known negative regulator of Notch signaling, enhances the activation of this pathway by facilitating the NICD translocation to the nucleus and increasing the upregulation and expression of the main downstream target, HES1, which has been widely linked to cancer progression and proliferation (69–71). The gene discussed is GSK3B; the disease is cancer.