ITGAM and neoplasm: Our results show that daily restraint stress increases PMN-MDSCs (CD11b+/Ly-6G+) frequency and decreases M-MDSCs (CD11b+/Ly-6C+) in the bone marrow and tumors of the ID8Luc model, with a notable increase in PMN-MDSCs during the later weeks of the experiment (weeks 3-4), corresponding to the tumor burden (Supplementary Figure S1A-C; Figures 2A–C).