To investigate the biological impact of chronic restraint stress on the Notch pathway in ovarian tumors, we assessed the expression of Notch pathway members (Notch1, Jagged2, NICD, HES1), β-adrenergic (ADRB2) receptors, glucocorticoid (GR) receptors, and pS9-GSK3β in tumors from both syngeneic mouse models (ID8Luc and IG10Luc) using IHC. This evidence concerns the gene JAG2 and ovarian neoplasm.