The high-risk group of patients is mainly distributed in Child-Pugh B and C-grade, BCLC staging C-D, underlying coronary heart disease, comorbidities with hepatic encephalopathy and vascular metastasis, larger tumor diameter, multiple tumors, poorer liver function, higher inflammatory indicators NLR and CRP, and higher AFP (Figure 6C, Supplementary Table S2, p<0.05). This evidence concerns the gene CRP and neoplasm.