In vitro experiments showed that both 1928zT2 T cells and m28zT2 T cells (with the TIR domain integrated) exhibited higher killing percentages against target tumor cells, increased secretion of IL-2, IFN-γ and GM-CSF, and better expansion upon serial stimulations compared to control cells, even at low effector to target (E/T) ratios. Here, IFNG is linked to neoplasm.