Building on findings from other autoimmune diseases where aberrant DNA methylation and histone modifications dysregulate TLR genes, agents such as DNA methyltransferase inhibitors (e.g., 5-azacytidine) and histone deacetylase (HDAC) inhibitors (e.g., entinostat) could potentially restore balanced TLR expression (112). The gene discussed is HDAC9; the disease is autoimmune disease.