Comparative analysis of immune cell subsets between NC and RA groups showed that macrophages M0 (P < 0.01) and plasma cells (P < 0.01) were upregulated in RA, whereas T cells CD4 memory resting (P < 0.05), mast cells resting (P < 0.05), dendritic cells resting (P < 0.01), B cells naïve (P < 0.01), and T cells regulatory (Tregs) (P < 0.05) were significantly downregulated (Figure 6C). This evidence concerns the gene CD4 and rheumatoid arthritis.