γδTCR engagement with tumor-associated antigens (e.g., BTN2A1–BTN3A1 complexes, EphA2) rapidly triggers Ca2+ flux and ERK phosphorylation, while NKG2D signals through DAP10-mediated PI3K activation, enhancing cytotoxicity and cytokine production. The gene discussed is KLRK1; the disease is neoplasm.