Beyond acute nucleic acid sensing, PARPi can induce treatment-related cellular senescence in tumor and stromal compartments, generating a senescence-associated secretory phenotype (SASP) enriched in IL6, IL8 or CXCL8, CCL2, GM-CSF, and members of the TGF beta family (31–33). The gene discussed is CXCL8; the disease is neoplasm.