In colorectal cancer, the overexpression of glutamine transporters, SLC1A5 (154), SLC38A1/2 (155), and SLC6A14 (156), drives enhanced glutamine uptake—a key metabolic adaptation that enables CRC cells to survive and proliferate in the nutrient-limited tumor microenvironment. The gene discussed is SLC1A5; the disease is colorectal carcinoma.