The PI3K/Akt signaling axis is significantly activated in colorectal cancer (23), and enhanced PI3K/Akt signaling not only directly activates GLUT1/4, HK2, and PFKFB3/4 but also coordinates glucose metabolism, nucleotide metabolism, and amino acid synthesis via activation of the mTOR pathway (35). This evidence concerns the gene HK2 and colorectal cancer.