Furthermore, in colorectal cancer, activator protein-1 (AP-1) (109), AMPK (110), high mobility group A1 (HMGA1) (111), YAP/TAZ signaling (112), TGFβ1 (113), and HIF1α (114) can regulate lipid synthesis through SREBP1. This evidence concerns the gene SREBF1 and colorectal cancer.