To assess the role of SAA in tumor progression and anti-tumor immunity in vivo, we established a subcutaneous tumor model in C57BL/6 mice using LLC cells with h.SAA1 overexpression [SAAOE, considering that human and mouse SAA proteins are highly homologous (32)], or vector control (Wildtype) (Figures 5A, B). This evidence concerns the gene SAA1 and neoplasm.