A study discovered that β-N-acetylhexosaminidase (Amuc_2109), the secretion of A. muciniphila, improved the symptoms of DSS-induced colitis mice by inhibiting the activation of NLRP3 inflammasomes, and inhibited the subsequent generation of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) of mouse colonic tissues. The gene discussed is TNF; the disease is colitis.