In vitro cell lines: 22RV1 (AR-positive androgen-independent), C4-2, PC-3, DU-145, LNCaP, VCaPMurine models: Subcutaneous xenografts established using 22RV1 cellsClinical specimens: Radical prostatectomy specimens from 30 patients with PCa, including tumor tissue and adjacent normal tissue. The gene discussed is AR; the disease is posterior cortical atrophy.