Despite this response, downregulated Major Histocompatibility Complex I molecules (MHC I) expression and impaired interferon signaling pathways—including defective STAT1 phosphorylation (57, 58)—promote immune evasion, immunosuppression, and tumor immune inertia in PCa (Figure 2), characteristic of a “cold tumor” phenotype. Here, STAT1 is linked to neoplasm.