In vitro cell lines:C4-2B MDVR (Enzalutamide-resistant CRPC cells), C4-2B AbiR (Abiraterone-resistant CRPC cells), C4-2B APALR (Apalutamide-resistant CRPC cells), Myc-CaP (Androgen-sensitive PCa cells), Myc-CaP MDVR (Enzalutamide-resistant PCa cells)Murine models:Subcutaneous xenograft tumors established with Myc-CaP cells, Orthotopic prostate tumors generated using Myc-CaP MDVR cellsClinical specimens: Genomic profiling of the SU2C/PCF cohort. The gene discussed is MYC; the disease is prostate neoplasm.