RMP-IL-18mutE4 enhanced mIFNγ-secretion (~10x EC50, ~2x Emax) from mouse splenocytes activated with anti-CD3, as well as mouse splenocytes co-cultured with ROR1+ tumor cells and redirected to recognize the tumor using the ROR1 T-cell engager (38). The gene discussed is ROR1; the disease is neoplasm.