On the other hand, when we consider the tumor burden, a greater proliferation of CD4+ CAR-T cells was observed: Ki67 99.46% of CD4+ CAR-T (range 72.12 – 100) in HTB vs 80.64 (13.61 – 100) in LTB group, p = 0.03. The gene discussed is MKI67; the disease is neoplasm.