HLA-E and neoplasm: The augmented presence of immune ligand-receptor pairs such as IL-6, TNFSF13B, LGALS9-CD45, and HLA-E-KIR (Figure 6E) underscores the pivotal role of macrophages in modulating inflammatory responses, immune evasion, and reshaping the tumor microenvironment within the context of elevated LST1 expression.