Functional assays showed that shLST1-transfected cells exhibited significantly diminished migratory capacity (Figures 7A, D, p<0.01) and markedly reduced colony-forming ability (Figures 7B, E, p<0.001), consistent with the hypothesis that LST1 promotes ccRCC progression under high-glucose conditions. Here, LST1 is linked to nonpapillary renal cell carcinoma.