Notably enriched signal pairs such as ICAM1-ITGB2, MIF-CD74, COL1A2-CD44, and HLA-A/B/C/E indicated potential involvement in processes such as antigen presentation, cell recruitment, and immune evasion by tumor cells within the tumor microenvironment (Figures 3F, G). The gene discussed is ITGB2; the disease is neoplasm.