The augmented presence of immune ligand-receptor pairs such as IL-6, TNFSF13B, LGALS9-CD45, and HLA-E-KIR (Figure 6E) underscores the pivotal role of macrophages in modulating inflammatory responses, immune evasion, and reshaping the tumor microenvironment within the context of elevated LST1 expression. The gene discussed is TNFSF13B; the disease is neoplasm.