To assess the relevance of six potentially causal genes (excluding ENGASE due to negative results in Bayesian colocalization analysis) identified through PWAS, MR and Bayesian colocalization, we retrieved the lowest P-values for SNPs within ±1 Mb of each of the seven genes using summary statistics from the largest stroke GWAS to date (N = 1 308 064).14 The most significant P-values were below 5 × 10−8 for two genes (MMP12 and F11), indicating genome-wide significance, while the lowest P-values for SNPs in the remaining four genes ranged from 1.32 × 10−5 to 2.36 × 10−6 (Table S7 and Table 1). Here, MMP12 is linked to stroke disorder.