NTRK1 and cancer: The epidermal growth factor receptor (EGFR), a tyrosine kinase, plays a key role in regulating various biological functions, including cell movement, cell cycle progression, and cell adhesion.8 It was also the first discovered receptor tyrosine kinase associated with cancer.9 It is a transmembrane glycoprotein with a molecular weight of approximately 170 kDa and features a potential glycosylation at its N-terminal end.10,11 EGFR is a catalytically active receptor tyrosine kinase (RTK) that operates under strict regulatory mechanisms.