In this study, we firstly evaluated the value of several daily used blood markers such as CRP, ESR/CRP, PLT, albumin, CAR, and PNI in predicting the failure of PRABCSI in PJI treatment, and demonstrated that, compared with ESR/CRP, PLT, albumin, and PNI, CRP and CAR can predict the failure of PRABCSI in PJI treatment. This evidence concerns the gene ESR1 and juvenile polyposis syndrome.