Previous studies in hereditary cancer settings have established that CNVs account for around 7–10% of all pathogenic variants (PVs) and are not limited to BRCA1 and BRCA2 but also occur in other high or moderate risk genes, like PALB2, ATM, CHEK2, and RAD51C [6, 12, 19, 24, 25]. The gene discussed is PALB2; the disease is hereditary cancer.