TP53 and hepatocellular carcinoma: The HCT116 xenograft model of colon cancer and the p53/PTEN KO hepatocellular carcinoma mouse model are no exceptions, where tumor growth was suppressed in vivo.7,145 CFI-400945 delayed hepatic tumor growth TP53KO/MycOE or PTENKO/MycOE mice by recruiting immune cells, including CD4+/CD8+ T cells, natural killer cells, and macrophages.