,78 Moreover, in human hematopoiesis where MECOM variants are associated with HSC-related disorders,89 perturbation of MECOM by CRISPR (to mimic a genetic disease caused by MECOM haploinsufficiency) found that TXNIP, the human ortholog of murine Txnip, is significantly downregulated with loss of MECOM,67 in agreement with the HSC quiescence network identified in this work. Here, TXNIP is linked to hereditary disease.