Increased MAM formation has been detected in fibroblasts and post-mortem brain tissue from familial and sporadic AD patients, and AD-associated proteins (APP, BACE1, and γ-secretase components) are enriched at these sites patients (Pera et al., 2017; Area-Gomez et al., 2009; Area-Gomez et al., 2012). This evidence concerns the gene BACE1 and Alzheimer disease.