The CTAR3 domain binds to Ubc9, promoting SUMOylation modification of intracellular proteins and enhancing tumor migration ability. The CTAR1/CTAR2 domain activates the NF-κB pathway, upregulates the expression of SUMO and related regulatory proteins, and drives the formation of tumor-related phenotypes. This evidence concerns the gene NFKB1 and neoplasm.