Evidence indicates that HPV E6 induces the degradation of the deubiquitinating enzyme CYLD, thereby activating the NF-κB signaling pathway and promoting cervical cancer cell proliferation (HeLa, SiHa, and Me180) (An et al., 2008; Tilborghs et al., 2017). The gene discussed is NFKB1; the disease is cervical carcinoma.