For example, downregulation of the ACE2/Ang-(1-7)/Mas axis promotes breast cancer metastasis by activating the Store-Operated Calcium Entry (SOCE) and p21-activated kinase (PAK)/nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)/Snail1 pathways [57]. This evidence concerns the gene ACE2 and breast carcinoma.