ACE2 and neoplasm: Notably, right-sided colonic mucinous adenocarcinoma correlates with extracellular matrix remodeling, EMT, and interleukin (IL)-17 signaling, while that on the left side may downregulate the ACE2/Ang-(1-7)/Mas axis via differentially expressed proteins (reducing ACE2 and Ang-(1-7)), potentially promoting tumor progression and metastasis [58].