In the context of cancer, ACE2 shows an inverse correlation with the activation of several oncogenic pathways, such as cell cycle, transforming growth factor-beta (TGF-β), Wnt, and vascular endothelial growth factor (VEGF), thereby impeding tumor proliferation and epithelial-mesenchymal transition (EMT) [28-30]. The gene discussed is ACE2; the disease is neoplasm.