AKT1 and neoplasm: In MF, E2F5-related genes were associated with helicase activity, NAD+ nucleosidase/ADP-ribose generation activity, NAD(P)+ nucleosidase activity, and SH2 domain binding, indicating that E2F5 may support tumor cell proliferation and survival by regulating DNA unwinding (e.g., MCM proteins [24]), DNA damage repair (e.g., PARP1 [25]), and signal transduction (e.g., PI3K/AKT [26]).