Criteria for diagnosing remission in patients with pituitary ACTH-dependent CS have been well established, with morning serum cortisol values below 5 μg/dL (<138 nmol/L) or UFC below 28–56 nmol/d (<10–20 μg/d) within 7 days of selective tumor resection (39). The gene discussed is POMC; the disease is substance dependence.