• Exhibit persistent early-onset hyperglycemia within four months of post infection.• Several immunologic and metabolic disturbances, such as elevated chemokines (CCL8, CCL19, CCL25 etc.) that are associated with hyperglycemia observed within 18 weeks of post infection.• Elevated level of CCL25 is potentially linked to pancreas GDNF impaired insulin secretion. Here, INS is linked to Hyperglycemia.