REC8 and Infertility: Among the most promising: two variants in Doublesex and Mab-3 Related Transcription Factor 1 (DMRT1), which is known for the SCOS phenotype in mice and had already been reported in infertile men, a new variant in REC8 Meiotic Recombination Protein (REC8), which is essential for meiosis and already associated with infertility in men, as well as new variants in genes with moderate or limited evidence of correlation with the SCOS phenotype, but with existing data on animal models or other types of NOA (TEX15, KLHL10, DNMT3B and TEX14, See Figure 5).