It can also significantly reduce the activities of XDH and adenosine deaminase (ADA) in the liver, showing a strong uric acid-lowering effect; In addition, palmatine can also reduce the kidney damage induced by HUA by restoring the Keap1-Nrf2 pathway and inhibiting the TXNIP/NLRP3 inflammasome (52). The gene discussed is ADA; the disease is Nephropathy.