SLC22A12 and hyperuricemia: Studies have shown that the ethanol extract of Eucommia ulmoides cortex can significantly increase the mRNA expression of organic OAT1 and OAT3 in the kidneys of hyperuricemic rats, and at the same time significantly reduce the mRNA levels of GLUT9 and urate transporter 1 (URAT1), which proves its potential role in improving hyperuricemia (49).