LEAP2 and hyperinsulinism: Patients with hyperinsulinemia had significantly higher serum LEAP2 levels than those without hyperinsulinemia (median 24.6 ng/mL, range 9.95-79.1 ng/mL vs. 18.4 ng/mL, range 2.02-16.34 ng/mL; P = 0.021; Figure 2A).