2025 A study in patients with type 2 diabetes mellitus with mild cognitive impairment (T2DM-MCI) showed a significant decrease in plasma HSP27 levels and a significant negative correlation with the speed of information processing (Trail Making Test Part A, also known as TMTA) and executive function (Trail Making Test Part B, also known as TMTB). Here, HSPB1 is linked to type 2 diabetes mellitus.