Notably, liver-specific interventions such as siRNA targeting Cyclin M4 have been shown to reverse MASLD-associated social memory and sensorimotor deficits, restoring hippocampal synaptogenesis and mitochondrial function, which underscores the causal and therapeutically targetable nature of the liver-brain axis in MASLD-related neurological complications (49). This evidence concerns the gene CNNM4 and metabolic dysfunction-associated steatotic liver disease.