In contrast, they can regulate miR-204-3p/ homeodomain-interacting protein kinase 2 (HIPK2) and miR-1248 to promote ECs proliferation, migration, and angiogenesis and upregulate the mRNA and protein levels of pro-angiogenic factors VEGF-A, angiopoietin-1 (Angpt-1), and TGF-β, thereby improving diabetic foot ulcers (38, 39). This evidence concerns the gene HIPK2 and diabetic foot.