CRP and infection: Future validation must also include head-to-head comparison with established biomarkers (PCT, CRP) to determine incremental clinical value and address the single-platform dependency through multi-center studies using diverse hematology analyzers.Rigorous, large-scale prospective validation in a single-gate cohort of undifferentiated patients with suspected infection is imperative to assess the true accuracy, calibration, and clinical utility of this model before it can be considered for any clinical application.