These inhibitors specifically target γc chain receptor signaling while sparing the signaling pathways of immunoregulatory cytokines, such as IL-10R (TYK2/JAK1), IL-27R (JAK1/JAK2), and IL-35R (JAK1/JAK2) (9), which may contribute to preventing autoimmunity in the hair follicle. The gene discussed is JAK1; the disease is Autoimmunity.