In 2014, Dixon et al. found no CHAC1 upregulation after exposing HT-1080 (fibrosarcoma cell line) and Calu-1 (non-small-cell lung cancer) cells to artesunate, whereas in more recent studies, a significant increase in CHAC1 expression in Burkitt’s lymphoma cells was observed (Dixon et al., 2014; Wang et al., 2019). This evidence concerns the gene CHAC1 and non-small cell lung carcinoma.