TP53, encoded by the TP53 gene and mutated in over 50% of human cancers, is essential for cell-cycle regulation and the induction of programmed cell death; tumors harboring mutations in the tumor suppressor therefore exhibit high grade invasiveness and metastatic potential (Duffy et al., 2018; Silwal-Pandit et al., 2017). The gene discussed is TP53; the disease is cancer.