Pan-cancer analyses reveal that CHAC1 expression is highly variable, being upregulated in many cancers (e.g., breast, ovarian, lung, bladder carcinomas) and downregulated in others (e.g., certain head/neck, kidney, and brain cancers) (Li, D. et al., 2021; Sun et al., 2024; Zhang, T. et al., 2024). Here, CHAC1 is linked to urinary bladder carcinoma.