CHAC1 and Familial prostate cancer: Therefore, studies have investigated how CHAC1 is regulated in tumor cells and their microenvironment: Prostate cancer patients frequently develop resistance to docetaxel, a challenge in which cancer-associated fibroblasts (CAFs) have been shown to play a significant role through exosome-mediated signaling (Giraldo et al., 2019; Sun et al., 2018).