CHAC1 and cancer: Among these, artesunate, sevoflurane, dihydroartemisinin, brusatol, nisin, hederagenin, glaucocalyxin A, nootkatone, cannabinoids and ophiopogonin B successfully promote ferroptosis in diverse cancer cell types mediated by the ER stress branch ATF4-CHOP-CHAC1 (Besser et al., 2024; Joo et al., 2012; Lu et al., 2024; Wang et al., 2019; Wang et al., 2021; Wang et al., 2022; Wang et al., 2025; Xu et al., 2022; Yu et al., 2024; Zhang et al., 2022).