Notably, in obesity-related AMI models, Gal-3 synergizes with metabolic stressors (e.g., lipotoxicity) to amplify ER stress, leading to severe cardiomyocyte loss and fibrosis (Jimenez-Gonzalez et al., 2024). The gene discussed is LGALS3; the disease is obesity due to melanocortin 4 receptor deficiency.