LGALS3 and hydrops fetalis: Gagno et al. (2019) demonstrated that the Gal-3/Gal-3BP ratio significantly improved risk stratification for death and HF after MI compared to Gal-3 alone, likely reflecting the functional activity of Gal-3. Recent studies also explore combining Gal-3 with novel markers like thrombomodulin or pentraxin-3, showing potential for enhanced prediction, especially in distinguishing STEMI from NSTEMI risk profiles (Misirlioglu et al., 2025).